Caverject 20 Micrograms Powder For Solution For Injection

Predisposition to priapism eg, sickle cell anemia or trait, multiple myeloma, leukemia. If your erections caverject longer than one hour you may need a smaller dose. Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important. Caverject Impulse comes as a pre-filled syringe device with a glass cartridge containing a whitish powder alprostadil- the active medication separate to a clear fluid. Caverject Impulse R - Prescribing Information. The adverse drug reactions are listed in order of decreasing medical seriousness within each frequency category and system organ class. Although the usual contra-indication to intrapenile administration of a vasoconstrictor does not apply in the treatment of priapism, caverject, caution is advised when this option is exercised. By continuing to browse the site you are agreeing to our policy on the use of cookies. Extreme caution is required in patients with coronary heart disease, uncontrolled hypertension, cerebral ischaemia, and in subjects taking monoamine oxidase inhibitors. Penile fibrosis, including angulation, cavernosal fibrosis, fibrotic nodules and Peyronie's disease may occur following the intracavernosal caverject of alprostadil. If necessary, this may be followed by further aspiration of blood through the same butterfly needle. Marketing authorisation holder 8. Marketing authorisation number s 9. By continuing to browse the site you are agreeing to our policy on the use of cookies. Each syringe contains either 10 micrograms caverject 20 micrograms of the drug per 0. Doses of greater than 60 micrograms of alprostadil are not caverject. A half inch, 27 to 30 gauge needle is generally recommended. Search eMC: For erectile dysfunction of vasculogenic, psychogenic, or mixed aetiology, the initial dose is 2. Discontinue if penile angulation or cavernosal fibrosis develops. By continuing to browse the site you are agreeing to our policy on the use of cookies.

Blood creatinine increased, Blood pressure decreased, Heart rate caverject. Reproductive System and Breast Disorders. Not indicated, caverject. In the majority of cases, spontaneous detumescence occurred. For further information talk to your doctor. Alprostadil is present in various mammalian tissues caverjecg fluids. The first injections of alprostadil must be done by medically trained personnel. The most frequent adverse reaction after intracavernosal injection of alprostadil is penile pain. This information is intended for use by health professionals. Fit the 22 gauge caverject to the syringe. Sympathomimetics may reduce the effect of alprostadil. Name of the medicinal product 2. Reconstituted solutions are intended for single use only, they should be used immediately and not stored. Penile fibrotic conditions eg, anatomical deformation, angulation, cavernosal fibrosis, Peyronie's disease. Sign Up Log In Cancel. The frequency of priapism defined as an erection that lasts 6 hours or longer was czverject. Stress Management - - - Prostate Cancer: Partners and Accreditations This site complies with the HONcode standard for trustworthy health information: Qualitative and quantitative composition 3.

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The intracavernosal injection must be done under sterile conditions. Powder for solution for injection A caberject to off-white powder. Parenting information is caverjecct at Parenthub. If your erections last longer than one hour you may need a smaller dose. Regular follow-up of patients, with careful examination of the penis, caverject strongly recommended to detect caverject of penile fibrosis or Peyronie's disease. Powder for solution for injection A white to off-white powder. At the time of discharge from the clinic, the erection should have subsided entirely and the penis must be in a completely flaccid state. Both the side of the penis that is injected and the site of injection must be alternated; prior to the injection, the injection site must caverject cleansed with an alcohol caverject. Adjust volume to the required dose for injection. Therefore, a more consistent product delivery is produced when Caverject Water for Injection containing benzyl alcohol is used. There is no evidence of tissue retention of alprostadil or its metabolites following intravenous administration. Caverject is administered by direct intracavernous injection, caverject. If there is a response, there should be at least a 1-day interval before the next dose is given. For erectile dysfunction of vasculogenic, psychogenic, or mixed aetiology, the initial dose is 2, caverject. Excipients with known effect: Alprostadil would not be expected to have an influence on the ability to drive or operate machines.

Doses of greater than 60 micrograms of alprostadil are not recommended. G04B E01 Alprostadil is present in caverjec mammalian tissues and fluids. Urethral haemorrhage, Haematuria, Dysuria, Pollakiuria, Micturition urgency. Alprostadil may enhance the effects of antihypertensives, vasodilative agents, anticoagulants and platelet caverjecr inhibitors. The metabolites are excreted primarily by the kidney and excretion is caverject complete within 24 hours. Use immediately after reconstitution. Vasculogenic, psychogenic, or mixed etiology: Caverject uses a superfine needle for administration. Should an ensuing erection persist for more caverject one hour detumescent therapy please refer to Section 4. Caverject Impulse contains the active component alprostadil which is used in the treatment of male erectile dysfunction. Company contact details Pfizer Limited. Peyronie's disease, Penis disorder, Erection increased. Such agents should not be used caverject combination with alprostadil due to the potential for inducing prolonged erections. As with all superfine needles, the possibility of needle breakage exists. The adverse drug reactions are listed in order of decreasing medical seriousness within each frequency category and system organ class. Reconstituted solutions of alprostadil are intended for single use only, they should be used immediately and not caverject. Last updated on eMC: The pharmacotoxic signs of alprostadil are similar in all animal species and include depression, soft stools or diarrhoea and rapid caverjsct. Alprostadil should be used caverject caution in patients with cardiovascular and cerebrovascular risk factors. Sodium For the full list of excipients, see section 6. The efficacy, tolerability, and return of spontaneous erections were assessed from the patients' diaries and caverject interview at each clinic visit. The first injections of alprostadil must be done by medically trained personnel. In the majority of the cases, penile pain was rated mild or moderate in intensity, caverject.

Caverject

Following intracavernous injection of 20 micrograms of alprostadil, mean peripheral levels of alprostadil at 30 and 60 caverject after injection are not significantly greater than baseline levels of endogenous PGE 1. This site uses cookies. Not caverject. Sodium For the full list of excipients, caverjetc section 6. Musculoskeletal and Connective Tissue Disorders. Use immediately after reconstitution. It should not be injected into the top or underside of the penis or into any visible veins. Treatment with alprostadil should be discontinued in patients who develop penile angulation, cavernosal fibrosis, or Peyronie's disease. Patients on anticoagulants such as warfarin or heparin may have increased propensity for bleeding after the intracavernosal injection, caverject. These patients when using alprostadil should engage in sexual activity with caution. The majority of patients achieve a satisfactory response with doses in the range of 5 to 20 micrograms. Regular follow-up of patients, with careful examination of the penis, is strongly recommended to detect signs of penile fibrosis or Peyronie's disease. By continuing to browse the site you are agreeing to our policy on the use of cookies. Sign Up Log In Cancel. Each 1ml of reconstituted solution contains 8. In the majority of the cases, penile pain was rated mild or moderate in intensity. How Supplied: General neurological symptoms- weakness of limbs, numbness, cavernect or increased sensitivity to pain. Last updated on caverject Alprostadil is not intended for co-administration with any other agent for the treatment of erectile dysfunction see Section 4. Last updated on eMC:

Caverject uses a superfine needle for administration. The risk of benzyl alcohol toxicity depends on the quantity administered and the hepatic capacity to detoxify the chemical. Vasculogenic, psychogenic, or caverject etiology: Caverject is indicated for the treatment caverject erectile dysfunction in adult males due to neurogenic, vasculogenic, psychogenic or mixed aetiology. Available at URL: The medication needs to be injected into the shaft of an outstretched penis to have an effect, caverject. Use immediately after reconstitution. Treatment The initial dose of alprostadil in patients with erectile dysfunction of neurogenic origin secondary to spinal cord injury is 1. Enter medicine name or company Start typing to retrieve search suggestions. Any alprostadil entering the systemic circulation from the corpus cavernosum will be rapidly metabolised. Painful erection is more likely to occur in patients with anatomical deformations of the penis, such as angulation, phimosis, cavernosal fibrosis, Peyronie's disease or plaques. Not indicated. If there is a response, there should be at least a 1-day interval before the next dose is given. A half inch, 27 to 30 gauge needle is generally recommended. Any alprostadil entering the systemic circulation from the corpus cavernosum will be rapidly metabolised. Blood creatinine increased, Blood pressure decreased, Heart rate increased. The maximum dose of phenylephrine should be 1 mg, or adrenaline micrograms 5 ml of the solution.

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As an aid to aetiologic diagnosis. Reconstituted solutions caverject intended for single use only, they should be used immediately and not stored. Sympathomimetics may reduce the effect of alprostadil. Regular follow-up of patients, with careful examination caverject the penis, caverject, is strongly recommended to detect signs of penile fibrosis or Peyronie's disease. Alprostadil would not be expected to have an influence on the ability to drive or operate machines. Parenting information is available at Parenthub. Alprostadil should not be used in men for whom sexual activity is inadvisable or contraindicated. Caverject this still fails to resolve the priapism, urgent surgical referral for further management, which may include a shunt procedure, is required. Blood creatinine increased, Blood pressure decreased, Heart rate increased. How Supplied: This information is intended for use by health professionals. Pupil dilation. Premature and low-birth weight infants may be more caverject to develop toxicity. To view the changes to a medicine you must sign up and log in. Patients on anticoagulants such as warfarin or heparin may have increased propensity for bleeding after the intracavernosal injection. Withdraw slightly more than the required dose of Caverject solution, remove the 22 gauge needle, and fit the 30 gauge needle. Current Competitions. If still unsuccessful, intracavernous injection of alpha-adrenergic medication is recommended. If the duration is longer, the dose should be reduced. The spongy erectile tissue contained within the corpus caverject therefore gets filled with blood. Find out more here. The adverse drug reactions are listed in order of decreasing medical seriousness within each frequency category and system organ class.

Active ingredient

Alprostadil is not intended for co-administration with any other agent for the treatment of erectile dysfunction see Section 4. Treatment The initial dose of alprostadil in patients with erectile dysfunction of neurogenic origin secondary to spinal cord injury is 1. Overdosage was not observed in clinical trials with alprostadil. Sexual stimulation and intercourse can lead to cardiac and pulmonary events in patients with coronary heart disease, congestive heart failure or pulmonary disease. Needle breakage, with a portion of the needle remaining in the penis, has been reported and, in some cases, required hospitalisation and surgical removal. Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important. Qualitative and quantitative composition 3. Alprostadil should be used with caution in patients with cardiovascular and cerebrovascular risk factors. Powder for solution for injection A white to off-white powder. Caverject is not intended to be mixed or coadministered with any other products. Treat priapism immediately. Caverject is indicated for the treatment of erectile dysfunction in adult males due to neurogenic, vasculogenic, psychogenic or mixed aetiology. To reconstitute Caverject using the prefilled diluent syringe: How to use Caverject Impulse Caverject Impulse should only be used in men not women or children who are caverject safe and suitable to have sexual intercourse. General Disorders and Administration Site Conditions. Sympathomimetics may reduce the effect of alprostadil. Alprostadil should be used with caution in patients who have experienced transient ischaemic attacks or those with unstable cardiovascular disorders. Alprostadil did not affect rat spermatogenesis at doses times greater than the proposed human intrapenile dose. Caverject may be a useful adjunct to other diagnostic tests in the diagnosis of erectile caverject. Vasculogenic, psychogenic, or mixed etiology: To email a medicine you must sign up and log in. It is recommended that patients are regularly monitored e. Subsequent incremental increases of micrograms should be given until an optimal dose is achieved. A half inch, 27 to 30 gauge needle is generally recommended. Patients on anticoagulants such as warfarin or heparin may have increased propensity for bleeding after the intracavernosal injection.

caverject

Erythema, Rash, Hyperhidrosis, Pruritus. References Australian Medicine Handbook. Single pack containing a 5 ml clear, colourless, glass vial of Caverject 20 micrograms powder with a bromobutyl rubber stopper and an aluminium overseal with polypropylene flip-off cap Packs also each contain a syringe of solvent, a sterile 22G and a 30G needle plus a preinjection swab. Alprostadil would not be expected to have an influence on the ability to drive or operate machines. The metabolites are excreted primarily by the kidney and excretion is essentially complete within 24 hours. Alprostadil may enhance the effects of antihypertensives, vasodilative agents, anticoagulants and platelet aggregation inhibitors. There is no evidence of tissue retention of alprostadil or its metabolites following intravenous administration. If an erection lasts longer than four hours you should contact your doctor immediately as it may lead to permanent damage. Each 1ml of reconstituted solution contains 8. To reconstitute Caverject using the prefilled diluent syringe: Skin - - - Dr Joe: Not indicated. Using aseptic technique, insert a gauge butterfly needle into the corpus cavernosum and aspirate ml of blood. Doses of greater than 60 micrograms of alprostadil are not recommended. The presence of benzyl alcohol in the reconstitution vehicle decreases the degree of binding to package surfaces. Reproductive System and Breast Disorders. If still unsuccessful, intracavernous injection of alpha-adrenergic medication is recommended. Patients on anticoagulants such as warfarin or heparin may have increased propensity for bleeding after the intracavernosal injection. The pharmacotoxic signs of alprostadil are similar in all animal species and include depression, soft stools or diarrhoea and rapid breathing. The minimum amount of benzyl alcohol at which toxicity may occur is not known. Regular follow-up of patients, with careful examination of the penis, is strongly recommended to detect signs of penile fibrosis or Peyronie's disease. Single cavegject containing a 5 ml clear, colourless, caverject vial of Caverject 20 micrograms powder with a bromobutyl rubber stopper and an aluminium overseal with polypropylene flip-off cap Packs also each contain a syringe of solvent, a sterile 22G and a 30G needle plus a preinjection swab. Dizziness, headache caverject fainting. In patients infected with blood-borne diseases, this could increase the transmission of such diseases to their partner, caverject. The effective alprostadil dose ie, the dose producing penile rigidity adequate for intercourse and lasting up to 60 minutes was determined before caverjetc into the month self-treatment home phase. Does not protect against sexually transmitted diseases.

Reconstituted solutions are intended for single use only, they should be used immediately and not stored. Peripheral levels of the major circulating metabolite, oxo,dihydro-PGE 1 , increase to reach a peak 30 minutes after injection and return to pre-dose levels by 60 minutes after injection. Alprostadil is present in various mammalian tissues and fluids. Find out more here. Find out more here. Sympathomimetics may reduce the effect of alprostadil. Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important. The second dose should be 5 micrograms if there is a partial response, and 7. Penile fibrotic conditions eg, anatomical deformation, angulation, cavernosal fibrosis, Peyronie's disease. Penile pain, prolonged erection, penile fibrosis, inj site hematoma or ecchymosis, penis disorder, penile rash or edema, other local effects, dizziness. Caverject 20 micrograms powder for solution for injection. Blood pressure and pulse should be continuously monitored during the procedure. Underlying treatable medical causes of erectile dysfunction should be diagnosed and treated prior to initiation of therapy with alprostadil. Reevaluate every 3 months. Single pack containing a 5 ml clear, colourless, glass vial of Caverject 20 micrograms powder with a bromobutyl rubber stopper and an aluminium overseal with polypropylene flip-off cap. Underlying treatable medical causes of erectile dysfunction should be diagnosed and treated prior to initiation of therapy with alprostadil. Inject the 1 ml of diluent into the vial, and shake to dissolve the powder entirely. Doses of greater than 60 micrograms of alprostadil are not recommended. The potential for abuse of alprostadil should be considered in patients with a history of psychiatric disorder or addiction. You should be followed up by your doctor to ensure caberject do not develop scarring or thickening of the caverject of the penis, caverject.