Sildenafil Dosage

Example Generic Sildenafil Prescription: Dosr Sildenafil is not indicated for use by women. In a specific interaction study, where sildenafil mg was co-administered with recmmended in hypertensive patients, there was an additional reduction on supine systolic blood pressure of 8 mmHg. Qualitative and quantitative composition 3. There is a fold selectivity over PDE6 which is involved dose the phototransduction pathway in the retina. Pooling of the following classes of antihypertensive medication: Sildenafil is the active ingredient in Viagra. There was no increase in adverse events with the higher dose. There was no effect on sperm motility or morphology after single mg oral doses of sildenafil in healthy volunteers see section 4. There are sildenafil adequate and well-controlled studies in pregnant or breast-feeding women. Mechanism of action Sildenafil is an oral therapy for erectile dysfunction. Recommenxed for the treatment of erectile dysfunction, including sildenafil, should be used with caution in patients with anatomical deformation of the dosf such as angulation, cavernosal fibrosis or Peyronie's diseaseor in patients who have conditions which may predispose them to priapism such as sickle cell anaemia, multiple myeloma or leukaemia. In the event of an erection that persists longer than 4 hours, the patient should seek immediate medical assistance. There are no data on the interaction of sildenafil recommended non-specific phosphodiesterase inhibitors such as theophylline or dipyridamole. Non-clinical data revealed no special hazard for humans based on conventional studies dos safety pharmacology, repeated dose toxicity, genotoxicity, carcinogenic potential, and toxicity to reproduction and development. The postulated mechanism for this change in colour discrimination dildenafil related to inhibition of PDE6, which is involved in the phototransduction cascade of the retina. Sildenafil has no direct relaxant effect on isolated human corpus cavernosum but potently enhances the recommended effect of NO sildenafil this tissue. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Sildenafil is rapidly absorbed. Recommendec Dosage Medically reviewed on October 16, recommended dose of sildenafil, Concomitant administration with ritonavir: Clinical efficacy and safety. The mean steady state volume of distribution V d for sildenafil is l, indicating distribution into the tissues. Marketing authorisation number s 9. Sildenafil potentiates the hypotensive effect of nitrates see section 4.

Effects of sildenafil on other medicinal products. In healthy volunteers receiving sildenafil mg single doseless than 0. Adding Revatio R to bosentan therapy does not result in any beneficial effect on exercise capacity. The major circulating metabolite results from N-demethylation of sildenafil. Sildenafil should not be administered to men with rare hereditary problems of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Pharmaceutical form Film-coated tablet. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Respiratory, thoracic and mediastinal disorders. Avoiding Side Effects Your recommended writes a 40 mg prescription of generic sildenafil. This information is intended for use by health professionals. Mechanism of action Sildenafil is an oral therapy for erectile dysfunction. Effects on vision Cases of visual defects have been reported spontaneously in connection with the intake of sildenafil and other PDE5 inhibitors see section 4. Dry eye, Lacrimal disorder and Lacrimation increased Reporting of suspected adverse reactions. Increasing Your Dose Your doctor writes a 40 dose prescription of generic sildenafil. Summary of the safety profile The safety profile of Sildenafil Pfizer is based on 9, patients in 74 double-blind placebo-controlled clinical studies. White to off-white, rounded diamond-shaped tablets, of dimensions Serious cardiovascular events, including myocardial infarction, unstable angina, sudden cardiac death, ventricular arrhythmia, cerebrovascular recommended, transient ischaemic attack, hypertension and hypotension have been reported post-marketing in temporal association with the use of Sildenafil. Reporting dose adverse reactions after authorisation of the medicinal product is important. Sildenafil has no effect on visual acuity or contrast sildenafil.

Usual Adult Dose for Erectile Dysfunction

Blood pressure Patient advice: In order dose minimise the potential of developing postural hypotension in patients receiving alpha-blocker treatment, patients should be stabilised on alpha-blocker therapy prior to initiating recommmended treatment. Patients should be advised that in the event of any sudden visual defect, they should stop taking Sildenafil and consult a physician immediately see section 4. Women Sildenafil if not indicated for use by women. Non-clinical data revealed no special hazard for humans based on conventional studies of safety pharmacology, repeated dose toxicity, genotoxicity, carcinogenic recommendee, and toxicity to reproduction and development. The following patient groups were represented: Enter medicine recomkended or company Start typing to retrieve search suggestions. Has not been studied. Generic sildenafil is only approved to treat pulmonary hypertension. Single oral doses of sildenafil up to mg in healthy volunteers produced no clinically relevant effects on ECG. Marketing authorisation holder 8. It is not possible to determine whether these events are related sildrnafil to these factors or to other factors. Population pharmacokinetic analysis of recommejded trial data indicated a reduction in sildenafil clearance when co-administered with CYP3A4 inhibitors such as ketoconazole, erythromycin, cimetidine. There is a fold selectivity over PDE6 which is involved in the phototransduction pathway in the retina. Name of the medicinal product 2. Cases of non-arteritic anterior ischaemic optic neuropathy, recommended rare condition, have been reported spontaneously and in an observational study in connection with the intake of sildenafil and other PDE5 inhibitors see section 4. The dose of sildenafil has not been studied in the following sub-groups of patients and its use is therefore contraindicated: Nitric oxide then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate cGMP sildenafil, producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood. Erectile dysfunction sildenafil works by preventing the chemical process that recommended blood leave recommnded erect penis. Preclinical studies showed additive systemic blood pressure lowering effect when PDE5 inhibitors were combined with riociguat. Clinical efficacy and safety Two clinical studies were specifically designed to rrcommended the time window after dosing during which sildenafil could produce an erection in response to sexual stimulation. To bookmark a medicine you must sign up and log in. Your doctor can gradually increase your dose to 60 mg 3 tablets80 mg 4 tabletsor the maximum daily dose of sildenfail— mg 5 tablets.

Pharmacokinetics in special patient groups. Nicorandil is a hybrid of potassium channel activator and nitrate. In a specific interaction study, where sildenafil mg was co-administered with amlodipine in hypertensive patients, there was an additional reduction on supine systolic blood pressure of recommendes mmHg. Sidlenafil consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. In a recommended RigiScan study, sildenafil was still able to produce an erection in response to sexual stimulation hours post-dose. Co-administration of sildenafil with ritonavir is not advised see section 4. There is a fold selectivity over PDE6 which is involved in the phototransduction pathway in the retina. Name of the medicinal product 2. Clinical efficacy and safety. Generic sildenafil is only approved to treat pulmonary hypertension. Its effect is more potent on PDE5 than on other known phosphodiesterases. The co-administration of PDE5 inhibitors, including sildenafil, with guanylate cyclase stimulators, such as riociguat, is contraindicated as it may potentially lead to symptomatic hypotension see section 4. Grapefruit juice is a weak inhibitor of CYP3A4 gut wall metabolism and may give rise to modest increases in plasma levels of sildenafil. Concomitant use of riociguat with PDE5 inhibitors, recommended dose of sildenafil, including sildenafil, is contraindicated see section 4. For the full list sildenafil excipients, see section 6. These drugs are used to treat erectile dysfunction ED. Pharmaceutical form Film-coated tablet. Consider protective measures against sexually transmitted dose. This is most likely to occur within 4 hours post sildenafil dosing see sections 4. In the event of an erection that persists longer than 4 hours, the patient should seek immediate medical assistance. Gastro oesophagael reflux disease, Vomiting, Abdominal pain upper, Dry mouth. The corresponding additional reduction in supine diastolic blood pressure was 7 mmHg. The following groups were not well represented or excluded recommfnded clinical trials: Sildenafil had no effect on ritonavir pharmacokinetics. It is not possible to determine whether these events are related directly to these factors or to other factors.

Recommended dose of sildenafil

Sildenafil had no effect on ritonavir pharmacokinetics. These reports included dizziness and light-headedness, but not syncope. Use in patients taking other medicinal products With the exception of ritonavir for which co-administration with sildenafil is not advised see section 4. Concomitant use with other PDE5 inhibitors or other treatments for erectile dysfunction. White to off-white, rounded diamond-shaped tablets, of dimensions 9. Sign Up Log In Cancel. Co-administration of sildenafil with ritonavir is not advised see section 4. After oral dosing of sildenafil AUC and C max increase in proportion with dose over the recommended dose range mg. Based on decommended dose tolerability, the dose may be increased to mg or decreased to 25 mg. Respiratory, thoracic doze mediastinal recommended. In healthy volunteers receiving sildenafil mg single doserecommended dose of sildenafil, less than 0. Avoiding Side Effects Your doctor writes a 40 mg prescription of generic sildenafil. Prior to prescribing sildenafil, physicians should carefully consider whether their patients with certain underlying conditions recokmended be adversely affected by such vasodilatory effects, especially in combination with sexual activity. Sildenafil Sildenafil may have a minor influence on the ability to drive and use machines. The maximum recommended dosing frequency is once per day. Clinical sipdenafil and safety. Caution is recommended when selecting or adjusting dose in this population. Further information on clinical trials In clinical trials sildenafil was administered to more than patients aged Refer to our editorial policy for content sources and attributions. Concomitant administration of sildenafil to patients taking alpha-blocker therapy may lead to symptomatic hypotension in a few susceptible individuals. To view the changes to a medicine sildenafip must sign up and log in.

This information is intended for use by health professionals. Protein binding is independent of total drug concentrations. In addition, physicians should advise patients what to do in the event of postural hypotensive symptoms. Sildenafil has no effect on visual acuity or contrast sensitivity. Posology Use in adults The recommended dose is 50 mg taken as needed approximately one sildenafil before sexual activity. The ability to adjust your dose of ED medication is one of the best ways to find a treatment plan that works for your health, lifestyle, and relationship with your partner. Co-administration of sildenafil with ritonavir is not advised see section 4. Musculoskeletal and connective tissue disorders. Effects of other medicinal products on sildenafil In vitro studies: Find out more here. Serious cardiovascular events, including myocardial infarction, unstable angina, sudden cardiac death, ot arrhythmia, cerebrovascular haemorrhage, transient ischaemic attack, hypertension and hypotension have been reported post-marketing in temporal association with the use of Sildenafil. The maximum recommended dose is mg. Any recom,ended medicinal product or waste material should be disposed dose in accordance with local requirements. The mean maximum decreases in supine systolic blood pressure following mg oral dosing of sildenafil was 8. Last updated on eMC: Price, Dose Size, and Use The biggest difference between Recomended and generic sildenafil is the amount of active ingredient in each pill. Enter medicine name or company Start typing to retrieve search suggestions. In a study of healthy male volunteers, co-administration of the endothelin antagonist, bosentan, an inducer of CYP3A4 [moderate], CYP2C9 and possibly of CYP2C19 at steady state mg twice a day with sildenafil at steady state 80 mg three times a day resulted in Concomitant use with other PDE5 inhibitors or other dose for erectile dysfunction The safety and efficacy of combinations of sildenafil with other PDE5 Recommended, or other pulmonary arterial hypertension PAH treatments containing sildenafil REVATIOor other treatments for erectile dysfunction have not been studied, recommended dose of sildenafil. Although specific interaction studies were not conducted for all medicinal aildenafil, population pharmacokinetic analysis showed no effect of concomitant treatment on sildenafil pharmacokinetics when grouped as CYP2C9 inhibitors such as tolbutamide, warfarin, sildenafilCYP2D6 inhibitors such as selective serotonin reuptake inhibitors, tricyclic antidepressantsthiazide and related diuretics, loop and potassium sparing diuretics, angiotensin converting enzyme inhibitors, calcium channel blockers, beta-adrenoreceptor antagonists or inducers of CYP metabolism recommended as rifampicin, barbiturates. After oral dosing of sildenafil AUC and C max increase in proportion with dose over the recommended dose range mg. Each tablet contains 25 mg, 50 mg or mg of sildenafil as citrate Excipient with known effect: Agents for pulmonary hypertension Impotence agents.

Usual Adult Dose for Pulmonary Hypertension

Pharmacokinetics in special patient groups. In healthy volunteers receiving sildenafil sildenafil single doseless than 0. Your doctor can gradually increase your dose to 60 mg 3 tablets80 mg 4 tabletsor the maximum daily dose of sildenfail— mg 5 tablets. Posology Use in adults The recommended dose is 50 mg taken as needed approximately one hour before sexual activity. No relevant adverse effects were found in reproduction studies in rats and rabbits following oral administration of sildenafil. Studies with human platelets indicate that sildenafil potentiates the antiaggregatory effect of sodium nitroprusside in vitro. Sign Up Log In Cancel. This site uses cookies. Urologicals; Drugs used in erectile dysfunction. Agents for pulmonary hypertension Impotence agents. In cases of overdose, standard supportive measures should be adopted as required. Two clinical studies were specifically designed to assess the time window after dosing during which sildenafil could produce recommmended erection in response to sexual stimulation. Active ingredient sildenafil citrate. These additional recommended pressure reductions were of a similar magnitude to those seen when sildenafil was administered dose to healthy volunteers see section 5. In controlled clinical trials, the discontinuation rate due to sildenafil was low and similar to placebo. Enter sildnafil name or company Start typing to retrieve search suggestions. You find that a 20 mg dose 1 tablet gives you the erection you want. For the full list of excipients, see section 6.

Method of administration For oral use. Sildenafil 50 mg did not potentiate the increase in bleeding time caused by acetyl salicylic acid mg. Chest pain, Fatigue, Feeling hot. In the natural setting, i. Microcrystalline cellulose Calcium hydrogen phosphate anhydrous Croscarmellose sodium Magnesium stearate Film coat: In addition, initiation of sildenafil at a dose of 25 mg should be considered see sections 4. Sildenafil is rapidly absorbed. These additional blood pressure reductions were of a similar magnitude to those seen when sildenafil was administered alone to healthy volunteers see section 5. Concomitant use with other PDE5 inhibitors or other treatments for erectile dysfunction The safety and efficacy of combinations of sildenafil with other PDE5 Inhibitors, or other pulmonary arterial hypertension PAH treatments containing sildenafil REVATIO , or other treatments for erectile dysfunction have not been studied. Back to top Pfizer Limited contact details. Mechanism of action Sildenafil is an oral therapy for erectile dysfunction. Erectile dysfunction medication works by preventing the chemical process that lets blood leave an erect penis. Concomitant use with alpha-blockers. You find that a 20 mg dose 1 tablet gives you the erection you want. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.

recommended dose of sildenafil

Prior to prescribing sildenafil, physicians should carefully consider whether their patients with certain underlying conditions could be adversely affected by such vasodilatory effects, especially in combination with sexual activity. Nicorandil is a hybrid of potassium channel activator and nitrate. This information is intended for use by health professionals. Sildenafil 50 mg did not potentiate the increase in bleeding time caused by acetyl salicylic acid mg. Order before February 11th to get your delivery by Valentine's Day. There is a fold selectivity over PDE6 which is involved in the phototransduction pathway in the retina. In normal healthy male volunteers, there was no evidence of an effect of azithromycin mg daily for 3 days on the AUC, C max , t max , elimination rate constant, or subsequent half-life of sildenafil or its principal circulating metabolite. Sildenafil is not indicated for use by women. Non-clinical data revealed no special hazard for humans based on conventional studies of safety pharmacology, repeated dose toxicity, genotoxicity, carcinogenic potential, and toxicity to reproduction and development. Based on efficacy and tolerability, the dose may be increased step-wise to 50 mg up to mg as necessary. Therefore the use of such combinations is not recommended. The following groups were not well represented or excluded from clinical trials: Studies in vitro have shown that sildenafil is selective for PDE5, which is involved in the erection process. Price, Dose Size, and Use The biggest difference between Viagra and generic sildenafil is the amount of active ingredient in each pill. They just come in slightly different doses and Viagra costs more than sildenafil. Generic sildenafil is only approved to treat pulmonary hypertension. In healthy male volunteers, sildenafil at steady state 80 mg t. In controlled clinical trials, the discontinuation rate due to sildenafil was low and similar to placebo. Not all pack sizes may be marketed. Subscribe to free Drugs. Concomitant use with ritonavir. The safety of sildenafil has not been studied in the following sub-groups of patients and its use is therefore contraindicated: The maximum recommended dosing frequency is once sildenwfil day. Pharmaceutical form Film-coated tablet. Based on efficacy and tolerability, the dose may be increased step-wise to 50 mg up to mg as necessary.

Doses of mg did not result in increased efficacy but the incidence of adverse reactions headache, flushing, dizziness, dyspepsia, nasal congestion, altered vision was increased. Therefore sexual stimulation is required in order for sildenafil to produce its intended beneficial pharmacological effects. Use in patients taking other medicinal products. These additional blood pressure reductions were of a similar magnitude to those seen when sildenafil was administered alone to healthy volunteers see section 5. Respiratory, thoracic and mediastinal disorders. Lactose monohydrate 1 mg per 25 mg tablet 2 mg per 50 mg tablet 4 mg per mg tablet. Sildenafil 25mg, 50mg, mg film-coated tablets. Patients should be advised that in the event of any sudden visual defect, they should stop taking Sildenafil and consult a physician immediately see section 4. And they can only drop from 50 mg to 25 mg if side effects are a problem. In order to minimise the potential of developing postural hypotension in patients receiving alpha-blocker treatment, patients should be stabilised on alpha-blocker therapy prior to initiating sildenafil treatment. Method of administration For oral use. Sildenafil Dosage Medically reviewed on October 16, Active ingredient sildenafil citrate. The safety and efficacy of sildenafil was maintained in long-term studies. Throat tightness, Nasal oedema, Nasal dryness. White to off-white, rounded diamond-shaped tablets, of dimensions One of the benefits of generic sildenafil over Viagra is that sildenafil comes in smaller 20 mg dose tablets. Nicorandil is a hybrid of potassium channel activator and nitrate. The mean maximum decreases in supine systolic blood pressure following mg oral dosing of sildenafil was 8. Patients with increased susceptibility to vasodilators include those with left ventricular outflow obstruction e. Further information on clinical trials In clinical trials sildenafil was administered to more than patients aged Generic sildenafil is only approved to treat pulmonary hypertension. There was no evidence of favourable clinical effect of the combination in the population studied. Effects on vision Cases of visual defects have been reported spontaneously in connection with the intake of sildenafil and other PDE5 inhibitors see section 4. Tabulated list of adverse reactions.